Healthy Heart & Brain Support 60 Vcap

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• How to Use

Finally ONE PRODUCT that addresses MANY CONCERNS for the aging person. 

ONE advanced, potent, all-inclusive formulation that provides clinically effective doses. HEALTHY HEART & BRAIN SUPPORT works to optimize metabolic, cardiovascular & cerebral functions, without the necessity of multiple formulations and many pills. This provides a more efficient, lower cost solution that is easy & convenient.

By using HEALTHY HEART & BRAIN SUPPORT by PHYSICIANS RESEARCH, you can protect and improve your heart & brain health, regulate your sugar & fat metabolism, prevent clogged arteries & improper blood clotting, improve your memory & your cognitive functioning.

FOR DOCTORS

HAWTHORN Crataegus laevigata has been utilized medicinally worldwide and its use in the treatment of conditions relating to the cardiovascular system is comparable globally. Hawthorn berries have traditionally been used as heart tonics. The fruits and flowers are included in the Homeopathic Pharmacopoeia of India.

Hawthorn is a rich source of procyanidins and flavonoids including rutin, quercetin, vitexin, epicatechin, catechin, and proanthocyanidins. Hawthorn increases myocyte energy turnover which increased cardiac muscle contractile capabilities, and may improve coronary blood flow, vascular health and cardiac rhythms. It is presumed that the flavonoids are thought to inhibit vasoconstriction and actively dilate blood vessels. Hawthorn extracts have been shown to effectively reduce blood pressure, angina attacks and serum cholesterol levels and in preventing the deposition of cholesterol in arterial walls. Hawthorn appears to strengthen blood vessels, supporting cardiac function.

HEALTHY HEART & BRAIN Support contains 80 mg of HAWTHORN Crataegus laevigata,standardized to 1.8% vitexin rhamnoside, which is present to assist in maintaining cardiovascular health.

ARJUNA Terminalia arjuna is a deciduous tree found in abundance in India. Arjuna is the choice herb in Ayurvedic medicine for cardiovascular health. Arjuna supports healthy heart function, lipid metabolism, has antioxidant properties, and promotes healthy prostaglandin levels. Terminalia arjuna has been identified and researched for its putative lipid lowering and cardio protective activities.

The bark leaves and fruits of Terminalia arjuna have been used in indigenous systems of medicine and traditional administration of the botanical was consumed as an alcoholic decoction of the bark stem. The phytochemistry of Terminalia arjuna dried bark extract includes arjunic acid, gallic acid, ellagic acid, arjunin and terminic acid, glycosides such as arjunetin, arjunosides 1-1V, flavones such as arjunolone, tannis, oligomeric proanthocyanidines, essential oils and minerals such as calcium, magnesium, zinc and copper. Terminalia arjuna contains a high level of flavonoids and this may possibly account for its beneficial effects in coronary artery disease.

Several pharmacological mechanisms have been proposed to illustrate the mode of action ofTerminalia arjuna, specifically its high concentration of flavonoids: prevention of oxidation of LDL cholesterol, enhancement of endothelial derived nitric oxide activity, inhibition of endothelial activation, and inhibition of platelet aggregation.

HEALTHY HEART & BRAIN Support contains 80 mg of ARJUNA Terminalia arjuna to assist in maintaining cardiovascular health.

GUGGUL Commiphora wightii resin has a long history of use in Ayurveda to treat disorders of lipid metabolism. Results from animal studies provide evidence that Guggul has stimulatory effects on the thyroid gland.

The positive effects GUGGUL, Commiphora wightii, has on lipid metabolism assists in the HEALTHY HEART & BRAIN FACTOR’s ability to help maintain cardiovascular health, at a dose of 80 mg per capsule, standardized to 7.5% E- and Z-Guggulsterones.

GYMNEMA Gymnema sylvestre has historical use in the treatment of diabetes and is derived from the leaves of a tree native to Africa and India. The leaves of Gymnema sylvestre has been used as an adjunct in the treatment of diabetes mellitus in ancient India. Reported to contain glycosides and the peptide gurmarin, resins, gymnemic acids, saponins, stigmasteril, quercitol and several amino acid derivatives, Gymnema’s effect on carbohydrate metabolism has been suggested to be secondary to improving glucose uptake in tissues, increasing insulin secretion and increasing pancreatic beta cell activity and reproduction.

HEALTHY HEART & BRAIN Support contains 80 mg of GYMNEMA Gymnema sylvestre to help maintain cardiovascular health, healthy glucose metabolism and blood sugar regulation.

TAURINE, or 2-aminoethanesulfonic acid, was originally discovered in ox (Bos taurus) bile. This nonessential amino acid-like compound can be synthesized from the amino acid cysteine and is found in high abundance in the tissues of many animals, especially sea animals, and in much lower concentrations in plants, fungi, and some bacteria.

Taurine is important in several metabolic processes of the body, including stabilizing cell membranes in electrically active tissues, such as the brain and heart. It also has functions in the gallbladder, eyes, and blood vessels, and may have some antioxidant and detoxifying properties. Although taurine is present in most tissues, it is especially concentrated in the nervous system and platelets. Furthermore, taurine is involved in the maintenance of homeostasis of intracellular Na and intracellular Ca concentrations and in the balance of neurotransmitters. Taurine serves to enhance the redox potential of the platelets by increasing its glutathione concentration.

Functionally, Taurine is involved in many physiological processes including cardiac rhythm, contractile function, blood pressure, osmotic pressure, platelet & visual cell function, bile acid synthesis and cholesterol degradation, and detoxification of xenobiotics. Taurine is essential for cardiac function, as the most abundant amino acid in the heart. Research shows supplementation with Taurine supports healthy cholesterol levels, given its ability to convert cholesterol to bile acids. Taurine regulates intracellular calcium thus protecting heart muscle and cardiac function. Taurine reduces blood fluid volume through its effect on sodium and urine excretion, which modulates blood pressure, improving the cardiac workload. Taurine’s regulation of cell membrane electrical conductivity supports a stable, healthy cardiac rhythm.

HEALTHY HEART & BRAIN Support contains 80 mg of Taurine to assist in maintaining cardiovascular health.

GINKGO Ginkgo biloba leaf as stated in the NHPD monograph (June 2009), helps to enhance cognitive function, enhance memory and to support peripheral circulation. Standardized extracts of Flavonoid Glycosides and Terpene Lactones are used as per the majority of research studies.

Many studies underline the efficacy of Ginkgo biloba extract to improve cognitive function and memory, through increased cerebral blood flow. The primary active components within are ginkgo flavone glycosides and terpene lactones involved in enhancing cerebral microcirculation by supporting artery and capillary tone and elasticity, relaxing vascular walls, and supporting an anti-platelet aggregation activity.

More oxygen delivery to nerve cells results, which aids glucose utilization and enhances memory and cognitive functions. Oxidative damage is prevented to nerve cell membrances, mitochondria and biochemistry shifts to produce an anti-inflammatory effect by suppression of active nitrogen and oxygen reactive species production. Ginkgo also has been seen to enhance cholinergic activity, as age-related loss of acetylcholine (ACh) receptors is inhibited, and choline uptake is stimulated in the hippocampal neurons.

HEALTHY HEART & BRAIN Support contains 80mg of GINKGO Ginkgo biloba, standardized to 24% Flavonoid Glycosides & 6% Terpene Lactones, to assist in maintaining cardiovascular, cerebral & mental health, supporting peripheral circulation, enhancing memory and cognitive function.

COENZYME Q10 as stated in the NHPD monograph (2007), helps to maintain and/or support cardiovascular health. Vital organs including the heart, immune system, liver, kidney, brain and periodontal tissues require CoQ10 for ATP activation and protection against free radical damage. CoQ10 is an endogenous antioxidant vital to the mitochondrial electron transport chain, producing energy for these cells and high metabolism cardiac muscle cells. CoQ10 synthesis decreases with illness, aging, poor nutrient intake and some HMG-CoA reductase inhibiting medications. Various studies demonstrate the effectiveness of CoQ10 for healthy cardiovascular and neurological function. A study on 73 patients examined the benefit of 120 mg of CoQ10 to find significant improvements in cardiovascular function after 28 days.

HEALTHY HEART & BRAIN Support contains 60 mg of COENZYME Q10 to assist in maintaining cardiovascular health.

ALPHA LIPOIC ACID (ALA) is a naturally occurring dithiol compound synthesized enzymatically in the mitochondrion from octanoic acid. ALA is said to be a necessary cofactor for mitochondrial alpha-ketoacid dehydrogenase and serves a critical role in mitochondrial energy metabolism. Dietary sources of ALA are muscle meats, heart, kidney and liver in addition to fruits and vegetables to a smaller degree.

ALA, a full spectrum water- & lipid-soluble antioxidant providing both intra- and extracellular protection. ALA aids in regenerating other antioxidants, vitamins C, E and glutathione. ALA promotes healthy blood sugar balance as a cofactor in energy production, improving glucose transport into the cell. Thus, ALA improves insulin resistance in Non-Insulin Dependent Diabetes Mellitus (NIDDM). Patients with diabetes, liver issues or high exposures to toxins may benefit from ALA supplementation, as their internal production is compromised.

HEALTHY HEART & BRAIN Support contains 45 mg of ALPHA LIPOID ACID to assist in maintaining cardiovascular health.

N-ACETYL-L-CYSTEINE (NAC) Glutathione is the main antioxidant substrate in all tissues. N-Acetyl-L-Cysteine is known to effectively raise intracellular glutathione levels. There are two major known modes of action for N-Acetyl-L-Cysteine which is to act as a scavenger of free radicals and to augment intracellular levels of glutathione. N-Acetyl-L-Cysteine has been suggested to improve membrane-bound ionic pumps in erythrocytes. Pulmonary artery endothelial cells (CPAEC) demonstrates that treatment with N-Acetyl-L-Cysteine prevented CPAEC growth inhibition and death by propyl gallate which was accompanied by the attenuation of glutathione depletion.

HEALTHY HEART & BRAIN Support contains 45 mg of N-ACETYL-L-CYSTEINE to assist in maintaining cardiovascular health.

BETAINE Trimethylglycine can be consumed through the diet (wheat, beets, and spinach) or can be produced endogenously through oxidation of choline. Betaine is used as a therapy to lower plasma homocysteine levels. An elevated level of homocysteine (hyperhomocysteinemia) has been implicated as an independent risk factor for cardiovascular diseases.

Betaine and its precursor choline are also involved in lipid metabolism. There are two pathways of homocysteine metabolism via key enzymes, methionine synthase and cystathione beta-synthase, with the help of cofactors folate-cobalamin and vitamin B-6. A third enzymatic pathway includes the betaine-homocysteine methyl transferase which is most abundant in the tissues of the liver and kidney.

HEALTHY HEART & BRAIN Support contains 45 mg of BETAINE Trimethylglycine to assist in maintaining cardiovascular health, synergistically supporting methylation processes and maintaining normal homocysteine metabolism.

MAGNESIUM Magnesium bisglycinate According to the NHPD monograph (2007), Magnesium helps maintain good health by supporting healthy digestive functions. Specifically, Magnesium helps to metabolize carbohydrates, fats and proteins. In the cardiovascular system, Magnesium works as a strong vasodilator, with the ability to displace calcium from the surfaces of smooth muscle cells. Magnesium deficiency results in increased calcium flowing into vascular smooth muscle cells, which increases cardiac contractility and the potentiated vasoconstrictor effects. As such, Magnesium is an essential mineral for healthy cardiovascular function.

HEALTHY HEART & BRAIN Support contains 45 mg of MAGNESIUM, as Magnesium bisglycinate for optimal absorption and greater bioavailability, to assist in maintaining cardiovascular health.

POTASSIUM Potassium aspartate According to the NHPD monograph (2007), Potassium is added to the product to help maintain good health. Potassium is a factor in good health and is essential for the proper functions of cellular pathways used to obtain, store and utilize energy from fats, carbohydrates and proteins. Potassium is another cardio-supportive electrolyte, complementary to Magnesium, to maintain normal cardiac rhythm, blood pressure and cardiac energy production, critical to healthy cardiovascular function.

HEALTHY HEART & BRAIN Support contains 45 mg of POTASSIUM, as Potassium aspartate to facilitate cell-energetic properties of the mineral, to assist in maintaining cardiovascular health.

WATER HYSSOP Bacopa monnieri is a traditional Ayurvedic medicine that has been used for centuries as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative, and anti-epileptic agent. Memory enhancing effects have been attributed to the active constituent saponin Bacosides A and B.

HEALTHY HEART & BRAIN Support contains 45 mg of WATER HYSSOP, Bacopa monnieri which works to support cognitive function and memory enhancement.

BANABA Lagerstroemia speciosa is a tropical plant found in India, Southeast Asia and the Philippines. Despite growing in several countries, the shredded leaves are well known in the Philippines to be used as a treatment for diabetes and kidney disease. It is thought that Banaba extract standardized to 1% Corosolic acid, which is extracted from Banaba leaf, may lower blood sugar in people with Type II Diabetes. Corosolic acid is known for its insulin-like effect in regulating blood sugar, via facilitation of GLUT-4 translocation.

HEALTHY HEART & BRAIN Support contains 24 mg of BANABA Lagerstroemia speciosa,standardized to 1% Corosolic acid, to assist in maintaining cardiovascular health, through beneficial blood glucose regulation.

POLICOSANOL Saccharum officinarum is a mixture of long-chain aliphatic primary alcohols such as 1-octacosanol, 1-triacontanol, and others, originally isolated from sugar cane wax. Fifteen (15) double blind controlled clinical trials show Policosanol’s efficacy in reducing plasma total cholesterol and low density lipoprotein cholesterol (LDL-C) levels, inhibiting LDL oxidation, and increasing high density lipoprotein (HDL) cholesterol. This provides benefit on cardiovascular capacity, platelet function and eicosanoid balance.

HEALTHY HEART & BRAIN Support contains 10mg of POLICOSANOL, Saccharum officinarum, to assist in maintaining cardiovascular health.

TOOTHED CLUB MOSS Huperzia serrata Huperzine A is an alkaloid derived from Huperzia serratasynonym Lycopodium serratum, a member of Huperziaceae. It is thought to be a potent and selective acetylcholinesterase inhibitor (AChEI). AChEI causes an increase in acetylcholine levels which is a deficiency found in patients with Alzheimer’s disease (AD).

Qian Ceng Ta is a traditional Chinese medicine produced from the whole plant of Huperzia serrataand has been used for over 1000 years in China for treatment of a number of ailments, including contusions, strains, swellings, schizophrenia and myasthenia gravis. In vitro and in vivo pharmacological studies have demonstrated that Lycopodium alkaloids produce definite effects in the treatment of diseases that affect the cardiovascular or neuromuscular systems and that are related to cholinesterase activity.

HEALTHY HEART & BRAIN Support contains 10 mg of TOOTHED CLUB MOSS, Huperzia serrata,standardized to 1% Huperzine A to help enhance memory and cognitive function.

VINCAMINE Vinca minor (Periwinkle) According to the Complete German Commission E (1998), Periwinkle is used for circulatory disorders, metabolic support for the brain, improving its oxygen supply, prophylaxis of memory and concentration impairment, improvement of memory, thinking capacity and mental productivity, among other uses.

Vincamine is an alkaloid derived from the Small Periwinkle (Vinca minor) and has a selective vasoregulating action on cerebral circulation. Increased cerebral blood flow through cyclic GMP-induced myorelaxation causes regional vasodilation, improving erythrocyte flexibility and inhibition of platelet aggregation. Nerve cells increase their oxygen uptake which offsets any damage from hypoxic conditions. Improved mitochondrial respiration rate acts to increase glucose use and ATP production further enhancing the brain’s energy levels.

HEALTHY HEART & BRAIN Support contains 4 mg of VINCAMINE Vinca minor (Periwinkle) to help enhance memory and cognitive function.

JAPANESE KNOTWEED Polygonum cuspidatum of Polygonaceae, (dried root) is a well-known traditional drug in China as well as in Japan. It has been widely used for the treatment of suppurative dermatitis, gonorrhea, favus athlete’s foot, and hyperlipidemia in Chinese folk medicine. Polygonum cuspidatum has anti-diabetic effects as it lowers serum glucose levels. Trans-Resveratrol (t-RVT), a naturally occurring stilbene (3,4′,5-trihydroxystilbene), is a phytoalexin found in Polygonum cuspidatum. The richest natural source of resveratrol is Polygonum cuspidatum, a plant root extract which has been used in oriental folk medicine.

HEALTHY HEART & BRAIN Support contains 2 mg of JAPANESE KNOTWEED Polygonum cuspidatumto assist in maintaining cardiovascular health.

CHROMIUM Chromium polynicotinate provides support for healthy glucose metabolism and transport, enhancing insulin responsiveness in muscle and fat tissues through Glucose Tolerance Factor (GTF), which increases glucose uptake by target cells. Chromium has also demonstrated to promote and regulate healthy serum lipids, cholesterol, LDL and HDL cholesterol.

HEALTHY HEART & BRAIN Support contains 500 mcg of CHROMIUM, as Chromium polynicotinate, to support healthy glucose and lipid metabolism, thereby affecting cardiovascular health.

FOLATE Vitamin B9 is beneficial to improve cardiovascular health & risk as it’s essential for proper endogenous methylation activity, which lowers homocysteine levels. It is postulated that homocysteine causes vascular damage through promotion of atherosclerotic plaque development and enhanced platelet aggregation. Supplementation has shown to reduce circulating homocysteine levels in clinical trials, thereby supporting cardiovascular health.

HEALTHY HEART & BRAIN Support contains 199 mcg of FOLATE to assist in maintaining cardiovascular health.

VANADIUM Vanadyl sulfate is a mineral salt demonstrating insulin-like effects to improve glucose metabolism, by enhancing insulin receptors at tissue receptor sites. Studies have exhibited Vanadium’s insulin-mimetic action as its supplementation improves serum glucose regulation. Vanadium has shown to improve insulin sensitivity in Non-Insulin Dependent Diabetes Mellitus (NIDDM) patients.

HEALTHY HEART & BRAIN Support contains 182 mcg of VANADIUM as Vanadium sulfate, to assist in maintaining cardiovascular health.

VITAMIN B12 Methylcobalamin, the most potent, active coenzyme form of Vitamin B12 (Cobalamin), is more biologically active due to its greater availability than the cyanocobalamin form. In the brain, outside the mitochondrion, Methylcobalamin is the only active form.

Cyanocobalamin must be converted by the liver to Methylcobalamin for Vitamin B12 to act biochemically in the brain. This complex conversion from Cyanocobalamin may be obstructed due to nutritional inadequacies, enzyme dysfunctions or tissue abnormalities, creating Vitamin B12 deficiency in the brain.

Cobalamin deficiency manifests as peripheral neuropathy, irritability, dementia, depression, psychosis, megaloblastic anemia, and increased risk of myocardial infarction and stroke. Progressive, irreversible neurological and cognitive impairment may be prevented with early diagnosis and prompt treatment. Unfortunately, serum Cobalamin does not reflect tissue (functional) levels. Healthy serum Cobalamin levels do not rule out a functional deficiency in other tissues or fluids.

Methylcobalamin is integral in methylation reactions, but also for red blood cell (RBC) formation, brain & nervous system function and immune regulation. Methylcobalamin is beneficial to improve cardiovascular health & risk by ensuring proper endogenous methylation activity, which lowers homocysteine levels. Methylcobalamin, an essential cofactor for methionine synthase, facilitates this critical enzyme to allow homocysteine to synthesis methionine, reducing homocysteine levels. It is postulated that homocysteine causes vascular damage through promotion of atherosclerotic plaque development and enhanced platelet aggregation. Methylcobalamin supplementation has shown to reduce circulating homocysteine levels in clinical trials, thereby supporting cardiovascular health.

Folic acid supplementation with Methylcobalamin has also been shown to reduce total plasma homocysteine levels in hemodialysis patients whereas administration of Cyanocobalamin was less effective. Both Folic acid and Vitamin B12 are essential for the remethylation pathway to regain and maintain normal activity, so deterioration of this pathway is related to an inhibition of folate enzymes as well as Methylcobalamin deficiency. Cyanocobalamin may not be as effective in lowering homocysteine levels when transmethylation is impaired from .

Patients on a restrictive diet losing weight may worsen their depression even while taking antidepressants, as changes in diet can deplete neurotransmitters. Methylcobalamin participates in synthesis of S-adenosylmethionine (SAM), important for formation of the neurotransmitters dopamine and serotonin involved in mood regulation. Depression improves rapidly and entirely in patients taking Methylcobalamin. Methylcobalamin plays an integral role is sleep also, as serotonin is the precursor to melatonin.

Reversal of nerve damage and promotion of nerve cell regeneration has been suggested with Methylcobalamin, a crucial methyl donor to the myelin sheath which insulates nerve fibers. Recent studies suggest that Methylcobalamin may be beneficial for patients with various neuropathies.

Administration of methylcobalamin along with folic acid has also been shown to reduce total plasma homocysteine levels in hemodialysis patients whereas administration of cyanocobalamin was less effective. Both folic acid and vitamin B12 are required for the remethylation pathway to regain and maintain normal activity. Deterioration of this pathway is related to an inhibition of folate enzymes as well as deficiency of methylcobalamin. Cyanocobalamin may not be as effective in lowering homocysteine levels when the body’s ability to metabolize and transmethylate it into methylcobalamin is impaired.

HEALTHY HEART & BRAIN Support contains 100 mcg of VITAMIN B12, as Methylcobalamin, to assist in maintaining cardiovascular health.

Adult: 1 capsules 2X daily on an empty stomach

Recommended Dose: Adult: Take 1 capsule daily with food.

Recommended Use: Healthy Heart & Brain Support helps to enhance cognitive function, helps support peripheral circulation, helps to maintain cardiovascular health and is a factor in the maintenance of good health.

Duration of Use: Please consult health care physician if using medication beyond 4 weeks.

Cautions and Warnings: If you are taking cardiac glycosides such as digitalis/digoxin, beta-blockers (e.g. propranolol) or the calcium channel blockers (e.g. Diltiazem), acetylcholinesterase inhibitors, vasodilators, anticoagulant or anti-platelet medication, nitroglycerin, antibiotics, consult a health care practitioner prior to use. If you are taking any medications for diabetes, seizures, elevated blood pressure, irregular rhythms, high cholesterol, congestive heart failure, blood thinners and diuretics, consult a health care practitioner prior to use as this product may interact with medications for these conditions. If you have diabetes, cardiovascular disease, a heart condition, thyroid disorder, cystinuria, coagulation disorders and/or are at risk for bleeding, consult a health care practitioner prior to use. If gastrointestinal discomfort, headache and/or skin rash appear, discontinue use. Consult a health care practitioner if symptoms persist of worsen, if migraine occurs or frequency increases, or if nausea and vomiting persists or worsens. If you experience symptoms of hypotension (low blood pressure) such as light-headedness or dizziness, discontinue use and consult a health care practitioner. Erythema, migraines, insomnia, somnolence, irritability, dizziness, upset stomach, polyphagia, dysuria, weight loss, skin rash, nose and gum bleeding may occur, in which case, discontinue use. If you experience any irregular bleeding, discontinue use. 

Contraindications: If pregnant or breast feeding, do not use.

Hypoallergenic: This product contains NO gluten, dairy, beef, egg, corn, soy, peanut, pineapple, yeast, or sugar.

Do not use if bottle seal is broken or missing.

Store in a cool, dry place (59°F-85°F) away from direct light.

KEEP OUT OF REACH OF CHILDREN.